RNA sequencing of primary bone marrow-derived macrophages from MAPL KO and control mice.
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- MAPL regulates gasdermin-mediated release of mtDNA from lysosomes to drive pyroptotic cell deathNature cell biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301127_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1284105 and SRA study SRP595996. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9075890 KO_0h_rep1 KO_0h
- GSM9075891 KO_0h_rep2 KO_0h
- GSM9075892 KO_0h_rep3 KO_0h
- GSM9075893 KO_24h_rep2 KO_24h
- GSM9075894 KO_24h_rep3 KO_24h
- GSM9075895 KO_24h_rep1 KO_24h
- GSM9075896 KO_4_5h_rep1 KO_4_5h
- GSM9075897 KO_4_5h_rep3 KO_4_5h
- GSM9075898 KO_4_5h_rep2 KO_4_5h
- GSM9075899 WT_0h_rep1 WT_0h
- GSM9075900 WT_0h_rep2 WT_0h
- GSM9075901 WT_0h_rep3 WT_0h
- GSM9075902 WT_24h_rep2 WT_24h
- GSM9075903 WT_24h_rep1 WT_24h
- GSM9075904 WT_24h_rep3 WT_24h
- GSM9075905 WT_4_5h_rep3 WT_4_5h
- GSM9075906 WT_4_5h_rep1 WT_4_5h
- GSM9075907 WT_4_5h_rep2 WT_4_5h
- GSE272755 Transcriptional effects of lysosome stress on mouse bone marrow-derived macrophages and primary microglia 263 samples shares marrow-derived, macrophages, primary, bone
- GSE331360 Bulk RNA sequencing of bone marrow-derived macrophages from WT and Ch25h-KO mice under different treatment conditions 24 samples shares marrow-derived, macrophages, bone
- GSE279117 HIF1α deletion promotes mitochondrial repurposing in bone marrow-derived macrophages, but not in tissue-resident alveolar macrophages 24 samples shares marrow-derived, macrophages, bone
- GSE302734 Single-Cell RNA Sequencing Unravels Interactions between Macrophages and Fibroadipogenic Progenitors during Ectopic Bone Formation in FOP Mice 12 samples shares macrophages, bone
- GSE268828 Transcriptomic profile of monocytes/ macrophages from injured bone, muscle, skin or heart tissues of Treg-depleted mice 56 samples shares macrophages, bone
- GSE189297 RNA sequencing of wild type or calcineurin-deficient mouse bone marrow-derived dendritic cells stimulated with or without lipoarabinomannan (LAM) from Mycobacterium tuberculosis Aoyama-B 10 samples shares marrow-derived, bone
- GSE201128 The response to lipopolysaccharide (LPS) of bone marrow derived macrophages treated with oxysterol binding protein (OSBP) inhibitors 30 samples shares macrophages, bone
- GSE232854 Control of Mycobacterium abscessus pulmonary infection requires IFN- γ Induced formation of foam macrophages 22 samples shares macrophages, control
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.