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Simvastatin alleviates ConA-induced autoimmune hepatitis by inhibiting CD4+T cell activation via calcium-NFATC3 pathway

GSE301394 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/18 Platform GPL24247
Summary
The mevalonate pathway plays a crucial role in various immune disease and Hmgcr is the key enzyme of this pathway. In addition, simvastatin, as an inhibitor of Hmgcr , also exhibits therapeutic potential for acute liver injury such as APAP-induced toxicity and hepatic ischemia-reperfusion injury (HIRI). However,its effect in ConA-induced acute liver injury remains unclear.
Published in
Simvastatin Alleviates ConA-Induced Autoimmune Hepatitis by Inhibiting CD4(+) T Cell Activation via Calcium-NFATC3 Pathway
Wang X, Long T, Zhou L et al. · Inflammation 2026 · PMID 41618046 · doi:10.1007/s10753-026-02462-1
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Also filed as BioProject PRJNA1284922 and SRA study SRP596538. Searching any of these in the dataset finder brings you back here.

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