Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 16 distinct titles, 4 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitnessNature aging · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301534_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1285389 and SRA study SRP439583. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 20 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7427934 intest_uPAR_F_old
- GSM7427935 intest_uPAR_F_young
- GSM7427936 intest_uPAR_M_old
- GSM7427937 intest_uPAR_M_young
- GSM7427938 intest_UT_F_old
- GSM7427939 intest_UT_F_young
- GSM7427940 intest_UT_M_old
- GSM7427941 intest_UT_M_young
- GSM7913144 UPAR+ Male
- GSM7913145 UPAR+ Female
- GSM7913146 UPAR- Male
- GSM7913147 UPAR- Female
- GSM9081598 Young UT 1
- GSM9081599 Young UT 2
- GSM9081600 Young uPAR 1
- GSM9081601 Young uPAR 2
- GSM9081602 Old UT 1
- GSM9081603 Old UT 2
- GSM9081604 Old uPAR 1
- GSM9081605 Old uPAR 2
- GSE314547 Estradiol disrupts constitutive androstane receptor (CAR)-mediated bile acid homeostasis in a murine model of intrahepatic cholestasis of pregnancy (ICP), and this effect is reversed by CAR ligands 16 samples shares car, reverse
- GSE249753 Age-related epithelial defects limit thymic function and regeneration [single cell; Foxn1Lin] 3 samples shares regeneration, defects
- GSE240020 Age-related epithelial defects limit thymic function and regeneration 51 samples shares regeneration, defects
- GSE297315 Crotonate-activated histone H3K14 crotonylation enhances intestinal regeneration after injury 41 samples shares regeneration, intestinal
- GSE275296 H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium [cutandtag_enzyme_profiling] 12 samples shares regeneration, intestinal
- GSE201417 Gene expression profiles of cardiac neural crest cells during heart development 294 samples shares car
- GSE241587 Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin cardiomyopathy mice [sci-RNA-seq] 96 samples shares car
- GSE248585 A conserved epithelial wound-like transcriptional program driven by FOSL1 underlies malignant progression of pancreatic ductal adenocarcinoma (ssRNA-Seq) 46 samples shares car
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.