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Single-cell RNA-seq of isolated non-parenchymal cells from imiquimod-induced psoriasis mouse model.

GSE301650 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/01/01 Platform GPL24247
Summary
We applied 10x Genomics single-cell RNA sequencing to profile non-parenchymal liver cells (NPCs) in a psoriasis-like mouse model. The study focuses on immune and liver sinusoidal endothelial cell (LSEC) alterations along the skin–liver axis to elucidate mechanisms driving comorbid liver disease in psoriasis. Given that 30–50% of psoriasis patients develop liver involvement, this approach aims to identify maladaptive cellular crosstalk and potential therapeutic targets.
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Direct links to NCBI, no account and no request form: the whole study as GSE301650_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1285919 and SRA study SRP598186. Searching any of these in the dataset finder brings you back here.

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