Effects of Histidine restriction in DND-41 cells in vitro
RNA-seq (gene expression) · human · 25 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 25 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALLbioRxiv : the preprint server for biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301665_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1285945 and SRA study SRP598136. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 10 replicated groups read from 25 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9087090 100His3-D6 100His3-D
- GSM9087091 100His2-D6 100His2-D
- GSM9087092 100His1-D6 100His1-D
- GSM9087093 50His3-D6
- GSM9087094 50His2-D6 50His2-D
- GSM9087095 50His1-D6 50His1-D
- GSM9087096 25His3-D6 25His3-D
- GSM9087097 25His2-D6 25His2-D
- GSM9087098 125His3-D6 125His3-D
- GSM9087099 125His2-D6 125His2-D
- GSM9087100 125His1-D6 125His1-D
- GSM9087101 NoHis3-D6
- GSM9087102 NoHis2-D6
- GSM9087103 NoHis1-D6
- GSM9087104 100His1-D9 100His1-D
- GSM9087105 100His2-D9 100His2-D
- GSM9087106 100His3-D9 100His3-D
- GSM9087107 50His1-D9 50His1-D
- GSM9087108 50His2-D9 50His2-D
- GSM9087109 25His1-D9
- GSM9087110 25His2-D9 25His2-D
- GSM9087111 25His3-D9 25His3-D
- GSM9087112 125His1-D9 125His1-D
- GSM9087113 125His2-D9 125His2-D
- GSM9087114 125His3-D9 125His3-D
- GSE242184 In vitro pigmentation of human iPSC-derived retinal pigment epithelium cells is not indicative of their quality for cell transplantation 4022 samples shares vitro
- GSE287078 Time- and Dose-Dependent Effects of Irradiation on Endothelial and Tumor Endothelial Cells: Transcriptional, Molecular, and Functional Changes Driving Activation In Vitro and In Vivo 30 samples shares vitro
- GSE294481 Effects of Amino Acid Restriction on Decidualization of Human Endometrial Stromal Cells 12 samples shares restriction
- GSE297830 Stable lentiviral-mediated expression of Cytochrome P450 2D6 in HepaRG cells: New means for in vitro assessment of xenobiotic biotransformation and cytotoxicity. 90 samples shares vitro
- GSE310271 Prior targeted therapy treatment and cellular composition modulate the effects of Axl inhibition on myeloid cells in the human in vitro melanoma tumor microenvrionment 8 samples shares vitro
- GSE288316 Transcriptional plasticity of stromal cells amplifies their differentiation efficiency in vitro 51 samples shares vitro
- GSE307095 RNA-seq profiling of resting naive and CD27bright memory B cells and in vitro activated CD27bright memory B cells reveals differences in B-cell activation patterns in common variable immunodeficiency (CVID) 50 samples shares vitro
- GSE305135 Single-Cell Multiomic Atlas of Human Cortical Development in Down Syndrome - Neural Cells in vitro Basic Characterisation Bulk RNA-seq Dataset 45 samples shares vitro
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.