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Peripheral Substance P induces deficits in hippocampal synaptic plasticity and memory

GSE301993 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/20 Platform GPL24247
Summary
Substance P (SP) is a neuropeptide that functions in both the central and peripheral nervous systems. Although substance P-containing neurons convey nociceptive information to the spinal cord and regulate inflammatory responses in peripheral tissues, the impact of a peripheral rise in substance P on hippocampal functions such as spatial learning and memory remains unclear. Here, we show that chronic peripheral substance P significantly impaired performance in both the object place recognition (OPR) and novel object recognition (NOR) tests compared to saline controls. Electrophysiology revealed a marked reduction in CA3‑CA1 LTP without changes in basal synaptic transmission. RNA‑Seq identified 77 differentially expressed genes (DEGs), and enrichment analysis highlighted pathways related to synaptic transmission and learning/memory.
Published in
Peripheral substance P induces deficits in hippocampal synaptic plasticity and memory
Kim SY, Yoon KN, Ji J et al. · Molecular brain 2025 · PMID 40818973 · doi:10.1186/s13041-025-01242-6
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Also filed as BioProject PRJNA1288024 and SRA study SRP599240. Searching any of these in the dataset finder brings you back here.

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