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Villification of the intestinal epithelium is driven by Foxl1

GSE302290 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/05 Platform GPL24247
Summary
The primitive gut tube of mammals initially forms as a simple cylinder consisting of the endoderm-derived, pseudostratified epithelium and the mesoderm-derived surrounding mesenchyme. During mid-gestation a dramatic transformation occurs in which the epithelium is both restructured into its final cuboidal form and simultaneously folded and refolded to create intestinal villi and intervillus regions, the incipient crypts. Here we show that the mesenchymal winged helix transcription factor Foxl1, itself induced by epithelial hedgehog signaling, controls villification by activating BMP and PDGFRa as well as planar cell polarity genes in epithelial-adjacent telocyte progenitors, both directly and in a feed- forward loop with Foxo3. In the absence of Foxl1-dependent mesenchymal signaling, villus formation is delayed, the separation of epithelial cells into mitotic intervillus and postmitotic villus cells impaired, and the differentiation of secretory progenitors blocked. Thus, Foxl1 orchestrates key events during the epithelial transition of the fetal mammalian gut.
Published in
Villification of the intestinal epithelium is driven by Foxl1 through activation of PDGFRα and BMPs
Zhu G, Rozenberg G, Lahori D et al. · Nature communications 2026 · PMID 41735288 · doi:10.1038/s41467-026-69791-5
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Also filed as BioProject PRJNA1289816 and SRA study SRP599949. Searching any of these in the dataset finder brings you back here.

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