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Adipokine Adissp as a potential therapeutic agent for diabetes and cardiometabolic diseases

GSE302416 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/16 Platform GPL34290
Summary
Adipokine Adissp simultaneously promotes glucose disposal and energy expenditure in adipose tissue. Treatment with recombinant Adissp (rAdissp) protein normalizes hyperglycemia and provides pleiotropic cardiometabolic benefits in diabetic and obese mice, primarily through its actions in white adipose tissue. RNA-seq analysis of inguinal white fat reveals that rAdissp activates a comprehensive thermogenic program characterized by enhanced mitochondrial metabolism, Ucp1-mediated uncoupling, glycolysis, and fatty acid futile cycling.
Published in
Adissp activates insulin-independent glucose disposal and energy expenditure in white fat to treat diabetes and cardiometabolic disease
Huang L, Liu P, Chen Q et al. · Science advances 2026 · PMID 42030391 · doi:10.1126/sciadv.aed2780
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Also filed as BioProject PRJNA1290367 and SRA study SRP600230. Searching any of these in the dataset finder brings you back here.

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