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Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling

GSE302563 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/07/19 Platform GPL34284
Summary
Secondary lymphedema, a progressive disorder characterized by pathological fibroadipose tissue accumulation, is a common problem after cancer treatment and orthopedic surgery. It remains a therapeutic enigma due to its self-perpetuating fibrotic cascade and lack of disease-modifying therapies.Human skin tissue was collected from lymphedema patients and normal controls. Histological/immunofluorescence staining and RNA sequencing were performed. Fibrous tissue was observed in lymphedema samples. RNA sequencing and gene set enrichment analysis (GSEA) revealed significant downregulation of the peroxisome proliferator-activated receptor (PPAR) signaling in lymphedema tissue.
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Epigenetic reprogramming via EZH2 inhibition rescues fibroadipose pathogenesis in secondary lymphedema through activating PPARγ signaling
Chen Z, Yao Z, Wu M et al. · Journal of orthopaedic translation 2025 · PMID 41079990 · doi:10.1016/j.jot.2025.08.014
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Also filed as BioProject PRJNA1291192 and SRA study SRP600718. Searching any of these in the dataset finder brings you back here.

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