← BioTransfer GEO Dataset Finder
GEO series

The effect of TASL knockout on murine B cells following TLR9 stimulation

GSE302697 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/24 Platform GPL24247
Summary
TLR signalling and the IRF5 pathway play a critical role in the activation of inflammatory pathways in B cells. The recently identified innate immune adaptor, TASL, plays an essential role in this pathway, enabling the phosphorylation of IRF5 and thereby the activation of downstream inflammatory pathways. We here identify the role of TASL in primary ex vivo murine B cells, finding that in the absence of TASL, key Interferon stimulated genes (ISGs) and genes involved in cytokine production are downregulated after stimulation by the TLR9 ligand, CpG ODN.
Published in
The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice
Johnstone JC, Mitchell R, Vyse TJ et al. · PLoS biology 2026 · PMID 41785302 · doi:10.1371/journal.pbio.3003342
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE302697_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1291755 and SRA study SRP600936. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 8 more — browse all 8 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.