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Effect of Intestinal Microbiome on Chromatin Accessibility in Paneth Cells

GSE302951 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 7 samples Submitted 2026/07/09 Platform GPL19057
Summary
To assess epigenetic changes, ATAC-seq was performed on Paneth cells isolated from germ-free (GF) and specific pathogen-free (SPF) mice. The results revealed microbiome-dependent alterations in chromatin accessibility at key genomic loci involved in stemness regulation.
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Direct links to NCBI, no account and no request form: the whole study as GSE302951_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 7 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1292886 and SRA study SRP601651. Searching any of these in the dataset finder brings you back here.

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