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Characterization of CIC binding to chromatin in murine KP and KPCic cell lines

GSE303110 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/09/11 Platform GPL28330
Summary
CIC binding was determined in KP murine lung cancer cells in untreated cells as well as after treatment with trametinib to enhance CIC binding to DNA. As a negative control, CIC binding was also determined in KPCic cells that express a non-functional CIC incapable of DNA binding.
Published in
The repressor Capicua is a barrier to lung tumor development driven by Kras/Trp53 mutations
Ballesteros-González I, Hernández-Navas I, Brehey O et al. · EMBO molecular medicine 2025 · PMID 41219537 · doi:10.1038/s44321-025-00326-z
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Also filed as BioProject PRJNA1294186 and SRA study SRP602555. Searching any of these in the dataset finder brings you back here.

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