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LXR agonism elicits a pre-effector state in naïve CD8+ T cells [RNA-seq]

GSE303316 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/30 Platform GPL34328
Summary
Here, we analyze transcriptional profiles of naïve CD8+ T cells with versus without exposure to the synthetic LXR agonist RGX-104 in the absence of TCR stimulation.
Published in
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity
Ostendorf BN, Goldstein JG, Liu S et al. · The Journal of experimental medicine 2026 · PMID 41665603 · doi:10.1084/jem.20252290
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Also filed as BioProject PRJNA1294828 and SRA study SRP602698. Searching any of these in the dataset finder brings you back here.

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