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LXR agonism elicits a pre-effector state in naïve CD8+ T cells [ATAC-seq]

GSE303423 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/12/29 Platform GPL34328
Summary
Here, we assess chromatin accessibility profiles of naïve CD8+ T cells after 24 hours of exposure to either the LXR agonist RGX-104 or DMSO in the absence of TCR stimulation.
Published in
Liver-X-receptor agonism enhances T cell priming and activation to promote anti-tumor immunity
Ostendorf BN, Goldstein JG, Liu S et al. · The Journal of experimental medicine 2026 · PMID 41665603 · doi:10.1084/jem.20252290
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Also filed as BioProject PRJNA1295387 and SRA study SRP602926. Searching any of these in the dataset finder brings you back here.

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