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Long-chain fatty acid β-oxidation regulates embryonic development by H3K18 acetylation in mice [RNA-seq]

GSE303695 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/08/01 Platform GPL28330
Summary
Fatty acids are not only important as energy sources, but also playing crucial roles in maintaining cellular homeostasis.Inhibition of long-chain fatty acid β-oxidation (LCFAO) results in preimplantation developmental arrest, downregulated expressions of S phase-related genes, and loss of H3K18ac modification. By profiling the landscape of H3K18ac, we show that H3K18ac is enriched on the promoter regions of S phase-related genes and correlates with their expression. Taken together, we demonstrate that LCFAO could regulate mouse preimplantation development by H3K18ac, providing new evidence for metabolic-epigenetic crosstalk in regulating embryonic development.
Published in
Long-chain fatty acid β-oxidation regulates embryonic development by H3K18 acetylation in mice
Zheng K, Cui H, Tang Z et al. · Frontiers in cell and developmental biology 2025 · PMID 41415208 · doi:10.3389/fcell.2025.1683028
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Also filed as BioProject PRJNA1297098 and SRA study SRP603721. Searching any of these in the dataset finder brings you back here.

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