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Rps19bp1 cKO Xmlc2Cre E11.5 mouse heart RNAseq

GSE303775 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/02/18 Platform GPL24247
Summary
This study investigates the transcriptomic consequences of cardiomyocyte-specific deletion of Rps19bp1 during mouse embryonic development. Rps19bp1 encodes AROS (Active Regulator of SIRT1), a known negative regulator of p53. To understand its role in cardiac development and cell cycle regulation, we performed RNA sequencing (RNA-seq) on ventricular heart tissues from E11.5 embryos of Rps19bp1 conditional knockout (cKO) mice and littermate controls. The data reveal widespread gene expression changes and activation of p53 signaling in Rps19bp1-deficient hearts, providing mechanistic insights into how Rps19bp1 modulates cardiomyocyte proliferation and embryonic heart morphogenesis.
Published in
Transcriptional readthrough at Atf4 locus suppresses Rps19bp1 and impairs heart development
Zhang Z, Wu T, Chen Z et al. · Cardiovascular research 2026 · PMID 41248983 · doi:10.1093/cvr/cvaf237
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Also filed as BioProject PRJNA1297664 and SRA study SRP603963. Searching any of these in the dataset finder brings you back here.

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