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Single cell RNA sequencing of post-radiation mouse jejunum with or without DIZE

GSE303960 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/08/04 Platform GPL24247
Summary
In a radiation mass casualty event, exposed populations will suffer dose-dependent toxicity to multiple-organ systems. Although several therapies are FDA-approved for treatment of the hematopoietic acute radiation syndrome (H-ARS), there are no FDA-approved medical countermeasures (MCM) for either acute gastrointestinal injury (GI) or late multi-organ toxicities known as the delayed effects of acute radiation exposure (DEARE). Prior data suggest activation of the alternative renin angiotensin (RAS) enzyme angiotensin-converting enzyme 2 (ACE2) has therapeutic potential for mitigating multi-organ radiation injury, including GI acute radiation syndrome (GI-ARS). Here, we evaluated whether pharmacologic activation of ACE2 mitigates GI-ARS in rodent models and protects against DEARE in GI-ARS survivors.
Published in
Activation of Angiotensin-Converting Enzyme 2 Mitigates Gastrointestinal Acute Radiation Syndrome
Sharma GP, Nissen A, Gasperetti T et al. · International journal of radiation oncology, biology, physics 2026 · PMID 40967372 · doi:10.1016/j.ijrobp.2025.09.021
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Also filed as BioProject PRJNA1298309 and SRA study SRP604410. Searching any of these in the dataset finder brings you back here.

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