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HSPA1A can alleviate CFA-induced inflammatory pain by modulating macrophages

GSE304075 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/31 Platform GPL24247
Summary
Current clinical approaches for managing inflammatory pain are frequently accompanied by adverse effects, significantly compromising patients' quality of life. This study investigates the analgesic potential of murine HSPA1A protein administration in alleviating Complete Freund’s Adjuvant (CFA)-induced inflammatory pain. Findings indicate that HSPA1A mitigates CFA-induced mechanical allodynia positively correlated with macrophage abundance. Transcriptomic RNA sequencing suggests involvement of inflammation-associated pathways in plantar tissues after HSPA1A injection.
Published in
HSPA1A Can Alleviate CFA-Induced Inflammatory Pain by Modulating Macrophages
Zhang W, Xie X, Xiong X et al. · International journal of molecular sciences 2025 · PMID 41096856 · doi:10.3390/ijms26199591
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Also filed as BioProject PRJNA1298869 and SRA study SRP604707. Searching any of these in the dataset finder brings you back here.

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