Transcriptome analysis of liver tissue from patients with Autoimmune Hepatitis, Primary Biliary Cholangitis, and Chronic Hepatitis B
RNA-seq (gene expression) · human · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 11 samples: 3 × Liver aspiration samples from PBC vs 3 × Liver aspiration samples from AIH vs 3 × Liver aspiration samples from CHB vs 2 × Liver aspiration samples from PBC&AIHGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Transcriptomic profiling of autoimmune hepatitis identifies TRAT1 as an in vitro negative regulator of NK cell effector functionsFrontiers in immunology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304352_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1300441 and SRA study SRP605890. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9148490 Liver aspiration samples from PBC_1 Liver aspiration sample…
- GSM9148491 Liver aspiration samples from PBC&AIH_1 Liver aspiration sample…
- GSM9148492 Liver aspiration samples from AIH_1 Liver aspiration sample…
- GSM9148493 Liver aspiration samples from PBC&AIH_2 Liver aspiration sample…
- GSM9148494 Liver aspiration samples from AIH_2 Liver aspiration sample…
- GSM9148495 Liver aspiration samples from PBC_2 Liver aspiration sample…
- GSM9148496 Liver aspiration samples from PBC_3 Liver aspiration sample…
- GSM9148497 Liver aspiration samples from AIH_3 Liver aspiration sample…
- GSM9148498 Liver aspiration samples from CHB_1 Liver aspiration sample…
- GSM9148499 Liver aspiration samples from CHB_2 Liver aspiration sample…
- GSM9148500 Liver aspiration samples from CHB_3 Liver aspiration sample…
- GSE274114 Metabolic dysfunction-associated steatohepatitis reduces interferon and macrophage liver gene signatures in chronic HBV patients 39 samples shares hepatitis, chronic, liver
- GSE231432 HSC-derived exosomal miR-122- 5p inhibits EMT and fibrosis of intrahepatic biliary epithelial cells to alleviate primary biliary cholangitis 24 samples shares cholangitis, primary, biliary
- GSE221608 Transcriptome sequencing of normal intestinal mucosal tissues, paired primary CRC tissues and liver metastases lesions in participants of CRC 52 samples shares primary, liver
- GSE303271 RNA-seq of liver biopsies from patients with pediatric autoimmune liver disease 64 samples shares autoimmune, liver
- GSE217649 Bulk RNA sequencing for gene expression profileing of primary liver sinusoidal endothelial cells and iPSC-derived hepatic endoderm, septum mesenchymal cells, endothelial cells, and liver bud organoids 26 samples shares primary, liver
- GSE241466 Transcriptomic profiling of the intermediate cell carcinoma of the primary liver cancer 25 samples shares primary, liver
- GSE315534 Single-cell RNA sequencing of primary colorectal cancer, matched adjacent normal tissues, and paired liver metastases 15 samples shares primary, liver
- GSE297471 Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks [MPRA] 13 samples shares autoimmune, primary
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.