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ASNA1 CKO with XMCL-CRE+ E14.5 mouse heart RNAseq

GSE304685 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/08/10 Platform GPL24247
Summary
ASNA1 (also known as TRC40) is a key component of the tail-anchored (TA) protein targeting pathway. To investigate its role in the heart, we generated cardiomyocyte-specific ASNA1 conditional knockout (ASNA1 CKO) mice. RNA-seq analysis was performed on E14.5 embryonic heart to identify transcriptional changes caused by ASNA1 deficiency. Our results reveal that ASNA1 is essential for maintaining the stability of TA proteins and regulating vesicular transport in cardiomyocytes, which are critical for normal cardiac development and function.
Published in
ASNA1 is essential for cardiac development and function by regulating tail-anchored protein stability and vesicular transport in cardiomyocytes
Feng W, Zhang Z, Chen Z et al. · PLoS genetics 2025 · PMID 41370295 · doi:10.1371/journal.pgen.1011964
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Also filed as BioProject PRJNA1301908 and SRA study SRP606633. Searching any of these in the dataset finder brings you back here.

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