Loss of miR-9-2 Causes Cerebral Hemorrhage and Hydrocephalus by Widespread Disruption of Cell-Type-Specific Neurodevelopmental Gene Networks
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 15 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304879_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1303130 and SRA study SRP607405. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 15 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9158937 E12 miR-9-2 Knock-out female 1 cerebral cortex
- GSM9158938 E12 miR-9-2 Knock-out female 2 cerebral cortex
- GSM9158939 E12 miR-9-2 Knock-out male 1 cerebral cortex
- GSM9158940 E12 miR-9-2 Knock-out male 2 cerebral cortex
- GSM9158941 E12 miR-9-2 Wild-type female 1 cerebral cortex
- GSM9158942 E12 miR-9-2 Wild-type female 2 cerebral cortex
- GSM9158943 E12 miR-9-2 Wild-type male 1 cerebral cortex
- GSM9158944 E12 miR-9-2 Wild-type male 2 cerebral cortex
- GSM9158945 E16 miR-9-2 Knock-out female 1 cerebral cortex
- GSM9158946 E16 miR-9-2 Knock-out female 2 cerebral cortex
- GSM9158947 E16 miR-9-2 Knock-out male 1 cerebral cortex
- GSM9158948 E16 miR-9-2 Knock-out male 2 cerebral cortex
- GSM9158949 E16 miR-9-2 Wild-type female 2 cerebral cortex
- GSM9158950 E16 miR-9-2 Wild-type male 1 cerebral cortex
- GSM9158951 E16 miR-9-2 Wild-type male 2 cerebral cortex
- GSE255938 Effects of prenatal maternal immune activation and exposure to circadian disruption during adolescence: exploring the two-hit model of neurodevelopmental disorders 32 samples shares neurodevelopmental, disruption
- GSE295077 Cell-type-specific contributions to impaired blood-brain barrier and altered cerebral metabolism in prodromal 5XFAD mice 16 samples shares cell-type-specific, cerebral
- GSE282909 Widespread and cell-type-specific transcriptomic reorganization following mild traumatic brain injury 16 samples shares cell-type-specific, widespread
- GSE226208 Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex [spatial transcriptomics] 2 samples shares cell-type-specific, cerebral
- GSE325932 Disease-associated microRNA, miR-9-2, is required for the timing of retinal progenitor cell competence and the maintenance of Müller glial identity 32 samples shares mir-9-2
- GSE317803 Mild SARS-CoV-2 maternal infection in mice induces transient offspring neurodevelopmental aberrance 140 samples shares neurodevelopmental
- GSE297245 Prenatal and postnatal effects of gestational immune activation on synaptic and neurodevelopmental pathways via epigenetic mechanisms (RNA-seq) 84 samples shares neurodevelopmental
- GSE248222 Impact of Maternal Immune Activation and Sex on Placental and Fetal Brain Cytokine and Gene Expression Profiles in a Preclinical Model of Neurodevelopmental Disorders 64 samples shares neurodevelopmental
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.