GEO series
Toll-like Receptor 4 Induces Trained Innate Immune Tolerance in the Heart in a Model of Stress-induced Cardiomyopathy [ATAC-seq]
GSE305274
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2025/09/22
GPL34290
Summary
This study aimed to determine the mechanism by which TLR4 activation establishes cardiac protection in mice subjected to isoproterenol-induced cardiac injury. We performed bulk ATAC sequencing to determine if this was set up through epigenetic means, which would suggest a mechanism consistent with trained innate immune tolerance.
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Paper (PMID 40924855) ↗
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