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Effect of Has3 deficiency on gene expression in the aorta of a mouse model of abdominal aortic aneurysms

GSE305434 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2025/12/04 Platform GPL21493
Summary
HAS3-derived hyaluronan (HA) is implicated in inflammatory processes of multiple human diseases. Employing a model of Angiotensin II -induced abdominal aortic aneuryms (AAA), we here examine the gene expression profiles of the aorta from Has3-deficient (Apoe/Has3-DKO) and Has3-competent (Apoe-KO) mice. We find a set of 53 differentially regulated genes involved in inflammation and leukocyte cell migration. Specifically, CXCL3 was profoundly upregulated in the aorta of Apoe/Has3-DKO, together with the pathways 'Agranulocyte adhesion and diapedesis' and 'Granulocyte adhesion and diapedesis`. Our data highlight the role of HAS3 as regulator of inflammation and immune cell recruitment in the devlopment of AAA.
Published in
Hyaluronan synthase 3 deficiency lowers the incidence of ruptures of abdominal aortic aneurysms by reducing monocyte infiltration
Niemann V, Brack F, Rolauer L et al. · Frontiers in immunology 2025 · PMID 41280888 · doi:10.3389/fimmu.2025.1680246
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Also filed as BioProject PRJNA1305734 and SRA study SRP608860. Searching any of these in the dataset finder brings you back here.

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