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Eos maintains Treg homeostasis and plays a critical role in the function of recirculating thymic Tregs

GSE305537 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/12/05 Platform GPL34290
Summary
Eos, a member of the Ikaros family of transcription factors, is expressed by T regulatory cells (Tregs) and has been postulated to play a role in Treg suppression and maintenance of Treg stability. We demonstrate that expression of Eos was limited to a subpopulation of thymus-derived, activated Tregs and is undetectable in resting or activated T conventional cells (Tconvs). Eos associates with Helios, Foxp3 and Hdac1 and binds directly to the CD25 locus at a site identical to the Foxp3 binding site resulting in enhancement of CD25 expression. Studies in heterozygous female mice demonstrate that Eos is critical for Treg survival and activation. Eos+ Tregs also represent the major population of recirculating thymic Tregs, in which Eos plays a critical role in regulating their migration and suppression of Treg precursors in the thymus by competing for IL-2 and depleting MHC II from thymic dendritic cells (DCs).
Published in
Eos plays a critical role in Treg homeostasis and modulates the function of recirculating thymic Tregs in the control of Treg development
Xie X, Thornton AM, Tanwar S et al. · Cell reports 2026 · PMID 41474621 · doi:10.1016/j.celrep.2025.116838
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Also filed as BioProject PRJNA1306408 and SRA study SRP609142. Searching any of these in the dataset finder brings you back here.

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