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scRNA-seq analysis of the livers from the mice treated with a pan-integrin αV inhibitor after pIVCL

GSE305630 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/01 Platform GPL28457
Summary
We performed scRNA-seq analysis on the livers from the mice treated with a pan-integrin αV inhibitor, CWHM-12, after partial inferior vena cava ligation (pIVCL), a mouse model of congestive hepatopathy. The scRNA-seq analysis showed that integrin αV inhibition decreased the expression of YAP/TAZ target genes in pericentral LSECs and collagen expression in HSCs, caused by hepatic congestion.
Published in
Activation of the Integrin αV-YAP-CTGF Axis in Liver Sinusoidal Endothelial Cells Promotes Liver Fibrogenesis, Leading to Portal Hypertension and Liver Carcinogenesis in Congestive Hepatopathy
Kato S, Hikita H, Tsukamoto O et al. · Gastroenterology 2026 · PMID 41758081 · doi:10.1053/j.gastro.2025.11.014
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Also filed as BioProject PRJNA1307302 and SRA study SRP609629. Searching any of these in the dataset finder brings you back here.

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