RNA-seq data of MV4-11, Kasumi-1, and KG-1 cells treated with HDAC8 inhibitor 22d 10 μM and control
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- HDAC8 inhibition targets STAT3-MYC axis and synergizes with Venetoclax in KMT2A-rearranged acute myeloid leukemiaLeukemia · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE305655_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1307418 and SRA study SRP610037. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9181513 Kasumi-1 DMSO 12h rep1 Kasumi-1 DMSO 12h
- GSM9181514 Kasumi-1 DMSO 12h rep2 Kasumi-1 DMSO 12h
- GSM9181515 Kasumi-1 DMSO 12h rep3 Kasumi-1 DMSO 12h
- GSM9181516 Kasumi-1 HDAC8i 10μM 12h rep1 Kasumi-1 HDAC8i 10μM 12h
- GSM9181517 Kasumi-1 HDAC8i 10μM 12h rep2 Kasumi-1 HDAC8i 10μM 12h
- GSM9181518 Kasumi-1 HDAC8i 10μM 12h rep3 Kasumi-1 HDAC8i 10μM 12h
- GSM9181519 MV4-11 DMSO 12h rep1 MV4-11 DMSO 12h
- GSM9181520 MV4-11 DMSO 12h rep2 MV4-11 DMSO 12h
- GSM9181521 MV4-11 DMSO 12h rep3 MV4-11 DMSO 12h
- GSM9181522 MV4-11 HDAC8i 10μM 12h rep1 MV4-11 HDAC8i 10μM 12h
- GSM9181523 MV4-11 HDAC8i 10μM 12h rep2 MV4-11 HDAC8i 10μM 12h
- GSM9181524 MV4-11 HDAC8i 10μM 12h rep3 MV4-11 HDAC8i 10μM 12h
- GSM9181525 KG-1 DMSO 12h rep1 KG-1 DMSO 12h
- GSM9181526 KG-1 DMSO 12h rep2 KG-1 DMSO 12h
- GSM9181527 KG-1 DMSO 12h rep3 KG-1 DMSO 12h
- GSM9181528 KG-1 HDAC8i 10μM 12h rep1 KG-1 HDAC8i 10μM 12h
- GSM9181529 KG-1 HDAC8i 10μM 12h rep2 KG-1 HDAC8i 10μM 12h
- GSM9181530 KG-1 HDAC8i 10μM 12h rep3 KG-1 HDAC8i 10μM 12h
- GSE326946 Transcriptomic profiling of AML cell lines MV4-11 and Kasumi-1 treated with CK1α degrader PinA1 12 samples shares kasumi-1, mv4-11, treated
- GSE298864 Retinoic acid and ascorbate synergize to suppress myeloid leukemia via TET2 activation [MV4-11 RNA-Seq] 12 samples shares mv4-11, rna-seq
- GSE233722 Effect of RNF4 depletion on GSK3685032-induced gene expression changes in MV4-11 cells [RNA-seq] 12 samples shares mv4-11, rna-seq
- GSE296685 Targeting HDAC8 sensitizes tyrosine kinase inhibitors in the elimination of B-cell acute lymphoblastic leukemia cells through degradation of HIF-1α 9 samples shares hdac8, inhibitor
- GSE313448 Nynrin Sustains Leukemia Stem Cell Viability via TXNIP Destabilization to Maintain Redox Homeostasis and Confer Venetoclax Resistance [KG-1a RNA-Seq] 8 samples shares kg-1, rna-seq
- GSE268969 RNA-seq for MV4-11 cell line in either the absence or presence of IRF1 4 samples shares mv4-11, rna-seq
- GSE290907 ZDHHC12 palmitoylates HDAC8 and promotes the development of hepatocellular carcinoma associated with a diet high in saturated fatty acids 30 samples shares hdac8
- GSE334988 Transcriptomic profiling of PRMT2 wild-type and PRMT2 knockout KG-1a acute myeloid leukemia cells 9 samples shares kg-1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.