GEO series

RNA Sequencing of Lung Tissue in FTO-Overexpressing Mice Modeling Chronic Obstructive Pulmonary Disease

GSE305761 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/08/01 Platform GPL34290

Summary

Fat mass and obesity-associated protein (FTO) is linked to various diseases; however, its role in COPD remains unclear. We previously found that the expression level of FTO was significantly decreased in COPD models. To explore the downstream target genes and pathways of FTO, we conducted RNA sequencing on lung tissues from wild-type and FTO-overexpressing mice exposed to cigarette smoke. Here, we report that FTO plays a crucial role in regulating inflammation in COPD. We demonstrated that FTO expression can modulate several pathways, including the PI3K-Akt and MAPK signaling pathways, which are associated with inflammation. Transcriptomic analysis further revealed FTO-dependent alterations in genes associated with inflammation. Overall, our study enhances the understanding of the molecular mechanisms by which FTO contributes to the regulation of inflammation in COPD.

This dataset

Open GSE305761 in finder → Find more mouse RNA-seq datasets →

Download

Direct links to NCBI, no account and no request form: the whole study as GSE305761_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Whole study · RAW.tar ↓ Series matrix ↓ All supplementary files ↗ Raw reads on ENA ↗

Also filed as BioProject PRJNA1307564 and SRA study SRP609752. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.