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Transcription factor Etv3 controls the tolerogenic function of dendritic cells (RNA-seq of Etv3 KO Tregs)

GSE306680 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/13 Platform GPL24247
Summary
Dendritic cells (DC) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DC including tissue-derived migratory DC (migDC), and facilitates their homeostatic maturation and CCR7-dependent migration. Mice with global or DC-specific deletion of Etv3 manifested the expansion of CD25low regulatory T cells (Treg), spontaneous activation of conventional T cells, and multiorgan T cell infiltration. Etv3 deficiency exacerbated TLR7-driven systemic lupus erythematosus (SLE)-like disease, supporting the reported genetic association of human ETV3 with SLE. Etv3-deficient migDC upregulated multiple costimulatory molecules including OX40 ligand (OX40L/TNFSF4), whose blockade partially rescued the Treg abnormalities. These results identify Etv3 as an essential regulator of the tolerogenic function of DC, and implicate it in the regulation of human autoimmunity.
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Also filed as BioProject PRJNA1311616 and SRA study SRP613732. Searching any of these in the dataset finder brings you back here.

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