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Impaired store-operated Ca2+ entry in mouse epidermis

GSE306726 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/15 Platform GPL28457
Summary
The purpose of this study was to investigate the role of SOCE in the skin epidermis in vivo, using female mice with epithelial tissue-specific Stim1 and Stim2 knockout (Stim1/2 cKO) and control mice (Stim1/2fl/fl). This study found that SOCE dysfunction led to hyperkeratosis and impaired epidermal barrier function via Klk activation without affecting skin cell proliferation in vivo.
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Direct links to NCBI, no account and no request form: the whole study as GSE306726_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1311974 and SRA study SRP613898. Searching any of these in the dataset finder brings you back here.

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