Transcriptomic analysis and experimental verification reveal the involvement of PI3K/AKT signaling pathway in high-altitude cognitive dysfunction [6_OHG]
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 5 × brain tissue, Mod vs 4 × brain tissue, Con vs 4 × brain tissue, 6-OHGGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- 6-Hydroxygenistein Ameliorates High Altitude Brain Injury via Activating PI3K/AKT Signaling Pathway Based on Transcriptomic Analysis and Experimental ValidationDrug design, development and therapy · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE307180_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1314700 and SRA study SRP617451. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 13 samples.
How we read this: 3 replicated groups read from 13 sample titles; they account for 13 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9217723 brain tissue, Con_1 brain tissue, Con
- GSM9217724 brain tissue, Con_2 brain tissue, Con
- GSM9217725 brain tissue, Con_3 brain tissue, Con
- GSM9217726 brain tissue, Con_4 brain tissue, Con
- GSM9217727 brain tissue, Mod_1 brain tissue, Mod
- GSM9217728 brain tissue, Mod_2 brain tissue, Mod
- GSM9217729 brain tissue, Mod_3 brain tissue, Mod
- GSM9217730 brain tissue, Mod_4 brain tissue, Mod
- GSM9217731 brain tissue, Mod_5 brain tissue, Mod
- GSM9217732 brain tissue, 6-OHG_1 brain tissue, 6-OHG
- GSM9217733 brain tissue, 6-OHG_2 brain tissue, 6-OHG
- GSM9217734 brain tissue, 6-OHG_3 brain tissue, 6-OHG
- GSM9217735 brain tissue, 6-OHG_4 brain tissue, 6-OHG
- GSE290548 Transcriptomic analysis and experimental verification reveal the involvement of PI3K/AKT signaling pathway in high-altitude cognitive dysfunction 8 samples shares pi3k, akt, high-altitude, experimental, verification, involvement, dysfunction
- GSE288213 Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling 30 samples shares pi3k, akt, involvement
- GSE234578 PI3K/AKT signalling regulates mouse Inner Cell Mass (ICM) progenitor specification [scRNA-seq] 186 samples shares pi3k, akt
- GSE265767 PI3K/AKT signalling regulates mouse Inner Cell Mass (ICM) progenitor specification [FLASH-seq] 26 samples shares pi3k, akt
- GSE305628 Isobavachalcone ameliorates TNBS-induced Crohn’s disease-like colitis via GPR84-PI3K-AKT axis 18 samples shares pi3k, akt
- GSE308218 Protective effects of swimming exercises on murine tumor-induced cardiac inflammation and apoptosis by suppressing PI3K-AKT pathway 17 samples shares pi3k, akt
- GSE304488 EET Reduction Contributes to Granulosa Cell Senescence And Endometriosis-Associated Infertility Via the PI3K/AKT/mTOR Signaling Pathway 16 samples shares pi3k, akt
- GSE201806 Harmful algal bloom toxin microcystin-LR interferes with PP1-mediated PI3K/AKT/FOXO1 signaling in granulosa cells to disrupt ovarian follicle maturation and ovulation 15 samples shares pi3k, akt
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.