GEO series
OCIAD2 promotes epithelial to mesenchymal transition during mesendoderm specification of human pluripotent stem cells
GSE307502
Homo sapiens
Expression profiling by high throughput sequencing
21 samples
2026/08/03
GPL24676
Summary
The mitochondrial protein OCIAD2 is misexpressed in several cancers and neurodegenerative diseases. However, insights into its physiological role, particularly in the context of stem cell differentiation, remain unexplored. Our analyses report that OCIAD2 is expressed in undifferentiated human embryonic stem cells (hESCs) and is upregulated upon mesendoderm specification. Using bulk transcriptome analysis of CRISPR-Cas9 based OCIAD2 knockout and constitutive OCIAD2 expressing hESC lines, we identify that OCIAD2 modulation does not affect stem cell identity but alters their mesendoderm differentiation potential. Our results highlight that OCIAD2 regulates TGFβ, AKT, BMP signalling pathways to promote epithelial to mesenchymal transition during early mesendoderm specification of pluripotent stem cells.
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