GEO series

Transcriptomes of left ventricle under reverse remodeling in 4,6,8-week age mice

GSE308341 Mus musculus (mouse) RNA-seq (gene expression) 45 samples Submitted 2025/09/30 Platform GPL24247

At a glance

RNA-seq (gene expression) · mouse · 45 samples

What it is: RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism: Mus musculus (mouse)
Samples: 45 samples: 9 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get: A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.

Summary (written by the submitters)

Reversible neonatal ascending aorta constriction (Rev-nAAC), neonatal ascending aorta constriction (nAAC) or sham surgery was performed in newborn mice within 24h. At the 4th, 6th and 8th week, left ventricles were collected and used for RNA sequencing (n=5 per group).

This dataset

Open GSE308341 in finder → Find more mouse RNA-seq datasets →

Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE308341_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1330224 and SRA study SRP621246. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗

Study design

9 conditions, mostly with about 5 replicates each

sham,4w,LV ×5 sham,6w,LV ×5 sham,8w,LV ×5 nAAC,4w,LV ×5 nAAC,6w,LV ×5 nAAC,8w,LV ×5 Rev-nAAC,4w,LV ×5 Rev-nAAC,6w,LV ×5 +1 more

Supports a between-group comparison across 45 samples.

How we read this: 9 replicated groups read from 45 sample titles; they account for 45 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

GSM9242526 sham,4w,LV1 sham,4w,LV
GSM9242527 sham,4w,LV2 sham,4w,LV
GSM9242528 sham,4w,LV3 sham,4w,LV
GSM9242529 sham,4w,LV4 sham,4w,LV
GSM9242530 sham,4w,LV5 sham,4w,LV
GSM9242531 sham,6w,LV1 sham,6w,LV
GSM9242532 sham,6w,LV2 sham,6w,LV
GSM9242533 sham,6w,LV3 sham,6w,LV
GSM9242534 sham,6w,LV4 sham,6w,LV
GSM9242535 sham,6w,LV5 sham,6w,LV
GSM9242536 sham,8w,LV1 sham,8w,LV
GSM9242537 sham,8w,LV2 sham,8w,LV
GSM9242538 sham,8w,LV3 sham,8w,LV
GSM9242539 sham,8w,LV4 sham,8w,LV
GSM9242540 sham,8w,LV5 sham,8w,LV
GSM9242541 nAAC,4w,LV1 nAAC,4w,LV
GSM9242542 nAAC,4w,LV2 nAAC,4w,LV
GSM9242543 nAAC,4w,LV3 nAAC,4w,LV
GSM9242544 nAAC,4w,LV4 nAAC,4w,LV
GSM9242545 nAAC,4w,LV5 nAAC,4w,LV
GSM9242546 nAAC,6w,LV1 nAAC,6w,LV
GSM9242547 nAAC,6w,LV2 nAAC,6w,LV
GSM9242548 nAAC,6w,LV3 nAAC,6w,LV
GSM9242549 nAAC,6w,LV4 nAAC,6w,LV
GSM9242550 nAAC,6w,LV5 nAAC,6w,LV
GSM9242551 nAAC,8w,LV1 nAAC,8w,LV
GSM9242552 nAAC,8w,LV2 nAAC,8w,LV
GSM9242553 nAAC,8w,LV3 nAAC,8w,LV
GSM9242554 nAAC,8w,LV4 nAAC,8w,LV
GSM9242555 nAAC,8w,LV5 nAAC,8w,LV
GSM9242556 Rev-nAAC,4w,LV1 Rev-nAAC,4w,LV
GSM9242557 Rev-nAAC,4w,LV2 Rev-nAAC,4w,LV
GSM9242558 Rev-nAAC,4w,LV3 Rev-nAAC,4w,LV
GSM9242559 Rev-nAAC,4w,LV4 Rev-nAAC,4w,LV
GSM9242560 Rev-nAAC,4w,LV5 Rev-nAAC,4w,LV
GSM9242561 Rev-nAAC,6w,LV1 Rev-nAAC,6w,LV
GSM9242562 Rev-nAAC,6w,LV2 Rev-nAAC,6w,LV
GSM9242563 Rev-nAAC,6w,LV3 Rev-nAAC,6w,LV
GSM9242564 Rev-nAAC,6w,LV4 Rev-nAAC,6w,LV
GSM9242565 Rev-nAAC,6w,LV5 Rev-nAAC,6w,LV

+ 5 more — browse all 45 samples with per-sample file links →

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Search all mouse RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.