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Pyelonephritis decreases serum cholesterol and mitigates atherosclerosis severity despite systemic inflammation

GSE308447 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/27 Platform GPL24247
Summary
Urinary tract infections are common and often recur. Using a pyelonephritis mouse model, we investigated the interplay between renal and systemic inflammation. Bulk RNA sequencing analysis of kidneys collected 16 hours post-infection was performed to identify novel regulators and modulators of inflammatory pathways. Our results highlight key molecular signatures involved in both local and systemic immune responses, providing new insights into the regulatory networks underlying the pathophysiology of pyelonephritis.
Published in
Pyelonephritis decreases serum cholesterol and mitigates atherosclerosis severity despite systemic inflammation
Possenriede L, Sendtner GW, Falahat P et al. · American journal of physiology. Heart and circulatory physiology 2026 · PMID 41740624 · doi:10.1152/ajpheart.00914.2025
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Also filed as BioProject PRJNA1330608 and SRA study SRP621797. Searching any of these in the dataset finder brings you back here.

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