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MAIT cells at different developmental stages egress the thymus to colonize specific tissues and sense increases in peripheral ligands

GSE308509 Mus musculus Expression profiling by high throughput sequencing; Other 5 samples Submitted 2026/04/13 Platform GPL24247Platform GPL16417
Summary
MAIT but not iNKT cells can be selected by thymic epithelial cells, while both require CD4+CD8+ thymocytes for maturation. MAIT and iNKT cells have similar developmental dynamics and thymic-residency properties but proliferate at different developmental stages.MAIT cells exit the thymus in an S1PR-dependent manner at different maturation stages to colonize specific peripheral organs.PLZF+Tbet-RORgt- MAIT cells preferentially colonize the intestine in a CCR9-dependent manner.Thymic output contributes to peripheral MAIT and iNKT cell numbers at steady state. Thymic MAIT17 cells are activated and expand in colitis and after bacterial exposure.
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Also filed as BioProject PRJNA1330796 and SRA study SRP621923. Searching any of these in the dataset finder brings you back here.

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