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Study of the function of Hnrnpu in liver regeneration

GSE308654 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/17 Platform GPL24247
Summary
In this study, we explored the effects of RNA splicing on hepatocyte fate decision. We found spatial remodeling of hepatic lobule during liver regeneration by spatial transcriptome analysis in regenerative and control mouse model. We also reported cell heterogeneity of hepatocyte-organoids and found that splicing factors reprogram hepatocytes from single-cell resolution. To explore the detailed function of splicing factors, splicing inhibitors (Pladienolide B) were used to treated organoids, then total RNA were harvest for bulk RNA sequence. In summary, we found that splicing factors can promote the transformation of hepatocytes from metabolic state to proliferative state by spatial transcriptome, single-cell RNA sequencing, and bulk RNA sequencing.
Published in
Activation and Spatial Redistribution of RNA Splicing Factors Trigger Hepatic Regeneration
An Y, Lian J, Wei W et al. · Cellular and molecular gastroenterology and hepatology 2026 · PMID 41033443 · doi:10.1016/j.jcmgh.2025.101654
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Also filed as BioProject PRJNA1331810 and SRA study SRP622744. Searching any of these in the dataset finder brings you back here.

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