RHOT proteins link mitochondrial motility to cardiomyocyte sarcomere maturation
RNA-seq (gene expression) · mouse · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere MaturationCirculation research · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE308897_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1333362 and SRA study SRP625580. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9255252 13, control, d1
- GSM9255253 14, control, d1
- GSM9255254 22, control, d1
- GSM9255255 25, control, d1
- GSM9255256 56, control, d1
- GSM9255257 62, control, d1
- GSM9255258 29, DKO, d1
- GSM9255259 33, DKO, d1
- GSM9255260 35, DKO, d1
- GSM9255261 55, DKO, d1
- GSM9255262 69, DKO, d1
- GSM9255263 79, DKO, d1
- GSM9255264 m1022-Control
- GSM9255265 m1064-Control
- GSM9255266 m1066-Control
- GSM9255267 m1088-Control
- GSM9255268 m1091-Control
- GSM9255269 m1101-Control
- GSM9255270 m1026-DKO
- GSM9255271 m1046-DKO
- GSM9255272 m1067-DKO
- GSM9255273 m1092-DKO
- GSM9255274 m1124-DKO
- GSM9255275 m1128-DKO
- GSE328619 Peripartum-associated heart failure develops independently of RHOT proteins 36 samples shares rhot, proteins
- GSE261940 Soluble ST2 induces cardiac contractile dysfunction by repressing mitochondrial electron transport chain genes in cardiomyocytes during fulminant myocarditis 20 samples shares mitochondrial, cardiomyocyte
- GSE330298 Lamins gate nuclear and chromatin structures for cardiomyocyte maturation genes. 35 samples shares cardiomyocyte, maturation
- GSE239814 Mitochondrial signals mediate paternal effects on offspring metabolism (Smart-Seq) 221 samples shares mitochondrial
- GSE296763 Mitochondrial respiration is necessary for CD8 T cell proliferation and cell fate 99 samples shares mitochondrial
- GSE280699 The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age [RNA-seq] 78 samples shares mitochondrial
- GSE273310 DELE1 mitochondrial integrated stress response to CHCHD10 G58R protein misfolding in striated muscle [RNA-seq] 64 samples shares mitochondrial
- GSE330452 Diurnal regulation of Acyl-CoA synthetase 3 (ACSF3) governs rhythmic mitochondrial lysine-malonylation and daily hepatic metabolism 64 samples shares mitochondrial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.