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Peripartum-associated heart failure develops independently of RHOT proteins

GSE328619 Mus musculus (mouse) RNA-seq (gene expression) 36 samples Submitted 2026/05/27 Platform GPL24247
At a glance

RNA-seq (gene expression) · mouse · 36 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
36 samples: 6 conditions, mostly with about 6 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Peripartum-Associated Heart Failure Develops Independently of RHOT ProteinsInternational journal of molecular sciences · 2026
Summary (written by the submitters)
The present study investigates whether the expression of RHOT1 and RHOT2 proteins is required for pregnancy-associated adaptations in the maternal heart.
Published in
Peripartum-Associated Heart Failure Develops Independently of RHOT Proteins
Froese N, Sina E, Galuppo P et al. · International journal of molecular sciences 2026 · PMID 42278517 · doi:10.3390/ijms27114991
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE328619_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1455989 and SRA study SRP693541. Searching any of these in the dataset finder brings you back here.

Study design
6 conditions, mostly with about 6 replicates each
Control nulliparous ×6 iRhot1/2-KO nulliparous ×6 Control postpartum ×6 iRhot1/2-KO postpartum ×6 iRhot1/2-KO delivery ×6 Control delivery ×6

Supports a between-group comparison across 36 samples.

How we read this: 6 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.