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High PEEP activates ITGB1 inducing diaphragm fibrosis during prolonged mechanical ventilation

GSE309024 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/03 Platform GPL24247
Summary
Mechanical ventilation (MV) with high positive end-expiratory pressure (PEEP) is linked to ventilation-induced diaphragm dysfunction (VIDD), but the role of integrin beta-1 (ITGB1) in PEEP-associated diaphragm fibrosis remains unclear.
Published in
High PEEP Activates ITGB1, Inducing Diaphragm Fibrosis During Prolonged Mechanical Ventilation
Gong J, Jia J, He R et al. · Biomolecules 2025 · PMID 41154695 · doi:10.3390/biom15101466
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Also filed as BioProject PRJNA1333328. Searching any of these in the dataset finder brings you back here.

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