Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasis.
Single-cell RNA-seq · human · 17 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 17 samples: 13 × 230628_Flex_GPP vs 4 × 230712_Flex_HCGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dynamic neutrophil-keratinocyte communication network centered on IL-36/TNFSF15 responses characterizes inflammatory responses in generalized pustular psoriasisNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309097_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1333953. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 17 samples.
How we read this: 2 replicated groups read from 17 sample titles; they account for 17 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9260550 230628_Flex_GPP_10 230628_Flex_GPP
- GSM9260551 230628_Flex_GPP_11 230628_Flex_GPP
- GSM9260552 230628_Flex_GPP_12 230628_Flex_GPP
- GSM9260553 230628_Flex_GPP_13 230628_Flex_GPP
- GSM9260554 230628_Flex_GPP_1 230628_Flex_GPP
- GSM9260555 230628_Flex_GPP_2 230628_Flex_GPP
- GSM9260556 230628_Flex_GPP_3 230628_Flex_GPP
- GSM9260557 230628_Flex_GPP_4 230628_Flex_GPP
- GSM9260558 230628_Flex_GPP_5 230628_Flex_GPP
- GSM9260559 230628_Flex_GPP_6 230628_Flex_GPP
- GSM9260560 230628_Flex_GPP_7 230628_Flex_GPP
- GSM9260561 230628_Flex_GPP_8 230628_Flex_GPP
- GSM9260562 230628_Flex_GPP_9 230628_Flex_GPP
- GSM9260563 230712_Flex_HC_1 230712_Flex_HC
- GSM9260564 230712_Flex_HC_2 230712_Flex_HC
- GSM9260565 230712_Flex_HC_3 230712_Flex_HC
- GSM9260566 230712_Flex_HC_4 230712_Flex_HC
- GSE286154 TL1A(TNFSF15)-ENO1 axis promotes osteoarthritis by disrupting redox homeostasis via the PI3K/AKT pathway[II] 16 samples shares tnfsf15
- GSE307110 IL-36γ Armored CAR T Cells Reprogram Neutrophils to Induce Endogenous Antitumor Immunity 15 samples shares il-36
- GSE288484 Transcriptional network analysis of PTEN protein-deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication 197 samples shares communication
- GSE262073 A prospective, international, multisite comparison of platelet isolation techniques for genome-wide transcriptomics: Communication from the SSC of the ISTH 114 samples shares communication
- GSE297395 Extracellular vesicles and their RNA cargo facilitate bidirectional cross-kingdom communication between human and bacterial cells [RNA-Seq] 105 samples shares communication
- GSE247369 Pathogenic TSC2 variants alter developmental trajectories of human cortical organoids and perturb cell-cell communication networks 92 samples shares communication
- GSE211434 Diverse immune suppressing cancer communications with myeloid cells prevent T cell activation and recruitment and provide resistance to cell cycle inhibitor therapy 81 samples shares communication
- GSE247367 Pathogenic TSC2 variants alter developmental trajectories of human cortical organoids and perturb cell-cell communication networks [bulk RNA-seq] 80 samples shares communication
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.