Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 26 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 26 samples: 11 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotencyCell reports · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309187_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1334296 and SRA study SRP626450. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 11 replicated groups read from 26 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9259324 WT_Naive_P300_1 WT_Naive_P300
- GSM9259325 WT_Naive_P300_2 WT_Naive_P300
- GSM9259326 WT_Primed_P300
- GSM9259327 Primed_H3K27me3_Rep1 Primed_H3K27me3
- GSM9259328 Primed_H3K27me3_Rep2 Primed_H3K27me3
- GSM9261486 DMSO_Day5_Rep1 DMSO_Day5
- GSM9261487 DMSO_Day5_Rep2 DMSO_Day5
- GSM9261488 DMSO_Day5_Rep3 DMSO_Day5
- GSM9261489 PROTAC_Day5_Rep2 PROTAC_Day5
- GSM9261490 PROTAC_Day5_Rep3 PROTAC_Day5
- GSM9261491 PROTAC_Day_5_Rep_1
- GSM9261492 UNC_Day5_Rep1 UNC_Day5
- GSM9261493 UNC_Day5_Rep2 UNC_Day5
- GSM9261494 UNC_Day5_Rep3 UNC_Day5
- GSM9261495 DMSO_H2AK119ub_Rep1 DMSO_H2AK119ub
- GSM9261496 DMSO_H2AK119ub_Rep2 DMSO_H2AK119ub
- GSM9261497 DMSO_H3K27me3_Rep1 DMSO_H3K27me3
- GSM9261498 DMSO_H3K27me3_Rep2 DMSO_H3K27me3
- GSM9261499 PROTAC_H2AK119ub_Rep1 PROTAC_H2AK119ub
- GSM9261500 PROTAC_H2AK119ub_Rep2 PROTAC_H2AK119ub
- GSM9261501 PROTAC_H3K27me3_Rep2 PROTAC_H3K27me3
- GSM9261502 UNC_H2AK119ub_Rep1 UNC_H2AK119ub
- GSM9261503 UNC_H2AK119ub_Rep2 UNC_H2AK119ub
- GSM9261504 UNC_H3K27me3_Rep1 UNC_H3K27me3
- GSM9261505 UNC_H3K27me3_Rep2 UNC_H3K27me3
- GSM9602200 PROTAC_H3K27me3_Rep1 PROTAC_H3K27me3
- GSE309123 Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency - RNA-seq 9 samples shares connectivity, pluripotency, transition, enhancers, emergent, poising, primed, naive
- GSE270787 ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency 205 samples shares pluripotency, primed
- GSE270784 ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency [ChIP-seq] 107 samples shares pluripotency, primed
- GSE262846 Transcriptomic Analysis of SLE Disease Activity in Resting Naive (rN) and Transitional (T1T2) B cells 88 samples shares transition, naive
- GSE342939 Senescent activated naive B cells promote anti-citrullinated antigen T cell responses and the transition to clinical rheumatoid arthritis 78 samples shares transition, naive
- GSE275738 METTL3-dependent m6A RNA methylation represses transposable elements derived enhancers to suppress naïve pluripotency in human pluripotent stem cells 72 samples shares pluripotency, enhancers
- GSE263716 Epigenetic Analysis of SLE Disease Activity in Resting Naive (rN) and Transitional (T1T2) B cells 62 samples shares transition, naive
- GSE274217 METTL3-dependent m6A RNA methylation represses transposable elements derived enhancers to suppress naïve pluripotency in human pluripotent stem cells [RNA-Seq] 28 samples shares pluripotency, enhancers
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.