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Ythdc1-p300-Klf5 complex-mediated Golgi dysfunction promotes aortic aneurysm

GSE309196 Mus musculus (mouse) ChIP-seq / ATAC-seq (genome binding and open chromatin) 2 samples Submitted 2025/12/08 Platform GPL24247
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 2 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Mus musculus (mouse)
Samples
2 samples
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Ythdc1-p300-Klf5 Complex-Mediated Golgi Dysfunction Promotes Aortic AneurysmAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Summary (written by the submitters)
Klf5 and Golph3l-mediated regulation of Golgi morphology has been implicated in the development of apoptosis induced by diverse stress stimuli, and the loss of VSMCs caused by VSMCs apoptosis is a major factor leading to aortic wall thinning and aneurysm development. However, the molecular link between Klf5, Golph3l, and Golgi morphology alteration in the context of the aortic aneurysm is unclear.
Read the full summary ↓
Here, we show that apoptosis-induced proliferation (AIP) in VSMCs occurs in AD and AAA tissues of humans and mice. The upregulation of Golph3l by Klf5 facilitates TNF-α and TNFSF12 secretion from AngII-stimulated VSMCs by inducing the compaction of the Golgi, which is essential for AIP and aneurysm development. Mechanistic studies reveal that AngII-induced elevation of global m6A RNA level, especially m6A-Gm40097, is responsible for Golph3l upregulation and AIP in VSMCs. Further, m6A-Gm40097 mediates Klf5 interaction with Ythdc1 and p300 to form a transcription complex on the Golph3l promoter, unveiling a novel lncRNA m6A modification-dependent regulatory mechanism of chromatin remodeling and transcription activation.
Published in
Ythdc1-p300-Klf5 Complex-Mediated Golgi Dysfunction Promotes Aortic Aneurysm
Wang WL, Song ZX, Bu SM et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41317401 · doi:10.1002/advs.202512116
This dataset
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309196_RAW.tar (it can run to tens of gigabytes).

3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1334315 and SRA study SRP627166. Searching any of these in the dataset finder brings you back here.

Samples in this study

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