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Investigation of the Regulatory Mechanism of Dhx37 in Sertoli Cells Using snRNA-seq

GSE309389 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/10/02 Platform GPL24247
Summary
To investigate the regulatory mechanism of Dhx37 in Sertoli cells, snRNA-seq analysis was performed on testicular cells isolated from whole testes of wild-type and Dhx37-/- mice (CKO)at P60. After quality control, single-cell transcriptomes for both wild-type and Dhx37-/- mice were obtained. UMAP dimension reduction and visualization categorized the cells into ten distinct clusters: Round Spermatids, Elongating Spermatids, Spermatocytes, Spermatogonia, Leydig cells, Fibroblasts, Sertoli cells, Macrophages, Endothelial cells, and others, based on known marker genes.
Published in
Multi-omics analysis the effects of Dhx37 deficiency on testis development and nucleolar homeostasis
Jiang Y, Chen J, Ren Y et al. · Cell death discovery 2026 · PMID 41535247 · doi:10.1038/s41420-025-02875-1
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Direct links to NCBI, no account and no request form: the whole study as GSE309389_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1335939 and SRA study SRP629344. Searching any of these in the dataset finder brings you back here.

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