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RNA-seq analysis of p62 knockout in murine oral carcinoma MOC2 cells

GSE309456 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/12/31 Platform GPL30172
Summary
p62/SQSTM1 is an autophagy adaptor protein that regulates stress responses and contributes to tumor progression. To clarify its role in oral cancer, we generated p62 knockout clones of the murine oral carcinoma cell line MOC2 using CRISPR-Cas9. RNA-seq was performed on parental and p62-deficient cells to assess transcriptomic changes associated with p62 loss. The dataset includes raw FASTQ files and processed gene-level count matrices, providing a resource for the study of p62-dependent molecular pathways in cancer biology.
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Direct links to NCBI, no account and no request form: the whole study as GSE309456_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1336114 and SRA study SRP629474. Searching any of these in the dataset finder brings you back here.

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