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Bulk RNA-seq of CRH neuron_Ctr vs Tumor

GSE309463 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/06/18 Platform GPL30172
Summary
Bulk RNA sequencing was performed on fluorescence-activated cell sorting (FACS)-isolated CRH-expressing neurons from the hypothalamus of control and EO771 tumor-bearing mice. The objective was to determine how breast tumor development influences transcriptional programs in CRH neurons, including acute stress-related signaling, immune-neuroendocrine communication, and downstream pathway alterations. These datasets are intended for differential gene expression analysis, pathway enrichment, and hypothesis generation for future functional validation.
Published in
Aberrant hypothalamic neuronal activity blunts glucocorticoid diurnal rhythms in murine breast cancer
Gomez AM, Wu Y, Zhang C et al. · Neuron 2026 · PMID 41401811 · doi:10.1016/j.neuron.2025.11.019
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Also filed as BioProject PRJNA1336121 and SRA study SRP629418. Searching any of these in the dataset finder brings you back here.

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