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HDAC5 Deficiency Induces Intrinsic Resistance to KRASG12D Inhibition by Disrupting c-Myc Acetylation-Ubiquitination Homeostasis [ChIP-Seq]

GSE309501 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/10/04 Platform GPL11154
Summary
We found that HDAC5 deletion significantly enhances intrinsic resistance to MRTX1133 in KRASG12D mutant pancreatic cancer. Mechanistic studies show that HDAC5 deletion promotes resistance to KRASG12D inhibitors by sustaining the activation of the MAPK signaling pathway.
Published in
HDAC5 deficiency induces intrinsic resistance to KRAS inhibition by disrupting c-Myc acetylation-ubiquitination homeostasis
Chen T, Yu H, Wang K et al. · The Journal of clinical investigation 2026 · PMID 41379561 · doi:10.1172/JCI195814
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Also filed as BioProject PRJNA1336177 and SRA study SRP629565. Searching any of these in the dataset finder brings you back here.

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