Combination of PARP and KRASG12D Inhibitors Enhances Therapeutic Efficacy by Exploiting Vulnerabilities(scRNA)
Single-cell RNA-seq · mouse · 12 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × KPC1199, vehicle vs 3 × KPC1199, Combination vs 3 × KPC1199, ola vs 3 × KPC1199, 1133Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE309596_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1336310 and SRA study SRP629792. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9270219 KPC1199, vehicle_1 KPC1199, vehicle
- GSM9270220 KPC1199, vehicle_2 KPC1199, vehicle
- GSM9270221 KPC1199, vehicle_3 KPC1199, vehicle
- GSM9270222 KPC1199, Combination_1 KPC1199, Combination
- GSM9270223 KPC1199, Combination_2 KPC1199, Combination
- GSM9270224 KPC1199, Combination_3 KPC1199, Combination
- GSM9270225 KPC1199, ola_1 KPC1199, ola
- GSM9270226 KPC1199, ola_2 KPC1199, ola
- GSM9270227 KPC1199, ola_3 KPC1199, ola
- GSM9270228 KPC1199, 1133_1 KPC1199, 1133
- GSM9270229 KPC1199, 1133_2 KPC1199, 1133
- GSM9270230 KPC1199, 1133_3 KPC1199, 1133
- GSE290828 Harnessing STING Signaling and Natural Killer Cells to overcome PARP Inhibitor Resistance in Homologous Recombination Repair altered Breast Cancer [RNA-seq] 20 samples shares parp, combination
- GSE269680 CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma (spatial) 15 samples shares krasg12d, therapeutic
- GSE300887 Sequential Platinum and PARP Inhibition Enhances PD1 Immunotherapy Efficacy in Murine Brca2 Mutated Pancreatic Cancer [RNAseq_1] 13 samples shares parp, enhances
- GSE333360 Distinct neuroinflammatory effects of individual chemotherapeutics shape chemotherapy-induced peripheral neuropathy in a novel mouse model of CVAD combination regimen. 30 samples shares combination, therapeutic
- GSE226780 Immunomodulation by the combination of statin and matrix-bound nanovesicle enhances optic nerve regeneration 12 samples shares combination, enhances
- GSE272999 scRNA of the immune infiltrate of TRAMP-C1 allografts upon different androgen-deprivation therapeutic combinations 10 samples shares combination, therapeutic
- GSE337208 scRNA seq. of PDAC models treated with Kras inhibitors in combination with checkpoint immunotherapy 9 samples shares combination, inhibitors
- GSE296145 SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and TLR pathway therapeutic vulnerabilities 36 samples shares vulnerabilities, therapeutic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.