GEO series
Transcriptomic analysis of SW620-conditioned medium-treated THP-1 macrophages
GSE310306
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2025/11/18
GPL24676
Summary
Siglec-5 and Siglec-14, expressed on myeloid cells, share ligand-binding domains but have opposing signaling functions. While these paired receptors regulate macrophage immune responses against bacterial infection, their role in the tumor microenvironment remains unclear. We found that Siglec-14 expression in THP-1 macrophages, when exposed to CRC tumor-conditioned medium, induces a protumoral SPP1+ tumor-associated macrophage phenotype, with enrichment of angiogenic pathways.
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Paper (PMID 41398201) ↗
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