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Distinct contributions of Etv2+ and Flk1+ progenitors to endothelial, hematopoietic, and cardiac lineages

GSE310396 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/11/21 Platform GPL21103
Summary
The ETS family transcription factor ETV2, VEGFA and its receptor FLK1 are essential for hematopoietic, vascular and cardiac development. Here, we combine dual Etv2 and Flk1 lineage tracing with molecular profiling to define how mesoderm progenitors are allocated to hematopoietic, endothelial, cardiomyocyte and smooth muscle lineages. We demonstrate that hematopoietic, endothelial, and cardiac valves arise from dual Etv2+ and Flk1+ lineages and that Etv2+ and Flk1+ mesoderm contributing to the hemangiogenic fate is molecularly distinct from those generating muscle. Mechanistically, we show that ETV2 cooperates with the BAF chromatin remodeling complex to establish accessibility at ETV2 target loci. Loss of Baf155 expression reduces chromatin accessibility at ETV2 target loci and impairs hemangiogenic lineage specification. This work defines lineage relationships and the molecular circuitry underlying hemangiogenic specification during cardiovascular development.
Published in
Distinct contributions of Etv2(+) and Flk1(+) progenitors to endothelial, hematopoietic, and cardiac lineages
Alleyne D, Kim M, Wu J et al. · Cell reports 2026 · PMID 41420864 · doi:10.1016/j.celrep.2025.116733
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Also filed as BioProject PRJNA1365878 and SRA study SRP646702. Searching any of these in the dataset finder brings you back here.

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