Astrocytic FABP5 drives cerebellar white matter dysfunction in multiple system atrophy by promoting TNF signaling and ferroptosis
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 5 × Primary astrocytes, Control, vs 5 × Primary astrocytes, LPS, vs 5 × Primary astrocytes, LPS+shFABP5,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE310612_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1366577 and SRA study SRP646974. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 3 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9304487 Primary astrocytes, Control, rep1 Primary astrocytes, Con…
- GSM9304488 Primary astrocytes, Control, rep2 Primary astrocytes, Con…
- GSM9304489 Primary astrocytes, Control, rep3 Primary astrocytes, Con…
- GSM9304490 Primary astrocytes, Control, rep4 Primary astrocytes, Con…
- GSM9304491 Primary astrocytes, Control, rep5 Primary astrocytes, Con…
- GSM9304492 Primary astrocytes, LPS, rep1 Primary astrocytes, LPS,
- GSM9304493 Primary astrocytes, LPS, rep2 Primary astrocytes, LPS,
- GSM9304494 Primary astrocytes, LPS, rep3 Primary astrocytes, LPS,
- GSM9304495 Primary astrocytes, LPS, rep4 Primary astrocytes, LPS,
- GSM9304496 Primary astrocytes, LPS, rep5 Primary astrocytes, LPS,
- GSM9304497 Primary astrocytes, LPS+shFABP5, rep1 Primary astrocytes, LPS…
- GSM9304498 Primary astrocytes, LPS+shFABP5, rep2 Primary astrocytes, LPS…
- GSM9304499 Primary astrocytes, LPS+shFABP5, rep3 Primary astrocytes, LPS…
- GSM9304500 Primary astrocytes, LPS+shFABP5, rep4 Primary astrocytes, LPS…
- GSM9304501 Primary astrocytes, LPS+shFABP5, rep5 Primary astrocytes, LPS…
- GSE326115 Metabolic and Skeletal Muscle Dysfunctions Correlate with Fatigue-Like Behavior in an Animal Model of Multiple Sclerosis 30 samples shares dysfunction, multiple
- GSE238201 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq] 12 samples shares dysfunction, ferroptosis
- GSE337704 IL-33 as a component of NETs mediates CIAKI by promoting ferroptosis in tubular epithelial cells 12 samples shares ferroptosis, promoting
- GSE239946 Signatures of IL1b, IL6 and TNFa in immune cell-types 209 samples shares tnf
- GSE244320 RNA-sequencing analysis of colon RNA from mice with compound mutations of XBP1, caspase-8, TNFR1 and MLKL. 30 samples shares tnf
- GSE333494 Hippocampal CA3 Nex+ neuronal TNFR2 alleviates chronic neuropathic pain by sex-dependently engaging opioid and endocannabinoid pathways 26 samples shares tnf
- GSE298388 Modulation of Inflammatory Pain by Myeloid FABP5 12 samples shares fabp5
- GSE342477 Characterization of an Antagonistic Antibody reactive to human and mouse TNFR2 with Anti-tumor Capacity 9 samples shares tnf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.