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RNA-seq of PRDX6 Knockdown and Control A223 Squamous Cell Carcinoma Cells Treated With HDAC Inhibitor Largazole

GSE310671 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/05/01 Platform GPL24247
Summary
This dataset comprises RNA sequencing data generated from A223 squamous cell carcinoma cells with stable knockdown of PRDX6 or parental control, treated with either DMSO or 100 nM largazole (a class I histone deacetylase inhibitor) for 18 hours. The study investigates the role of PRDX6 in modulating ferroptosis susceptibility and inflammatory responses upon HDAC inhibition. Transcriptomic profiling was performed to evaluate pathway enrichment and gene expression signatures associated with ferroptosis, redox homeostasis, and immune activation. Results demonstrate that PRDX6 knockdown enhances largazole-induced ferroptotic and inflammatory transcriptional programs, implicating PRDX6 as a redox rheostat suppressing immunogenic stress responses in squamous carcinoma.
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Direct links to NCBI, no account and no request form: the whole study as GSE310671_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1366916 and SRA study SRP647199. Searching any of these in the dataset finder brings you back here.

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